Zotsekemera zophatikizika ndi zakudya zomwe zimapangidwa pophatikiza zotsekemera ziwiri kapena zingapo zachilengedwe kapena zopangidwa ndi mankhwala. Kupyolera mu zotsatira za synergistic, zimawonjezera kutsekemera, kumapangitsanso kukoma, ndi kuchepetsa ndalama, ndipo zimatha pang'onopang'ono kapena kwathunthu m'malo mwa sucrose.Zimakhala ndi zosakaniza zogwira ntchito monga stevia, AK shuga, ndi sucralose, ndipo zimapezeka mumitundu yolimba (granular, powdered) ndi madzi, mogwirizana ndi muyezo wa GB26687-2011. Matekinoloje awo ovomerezeka amaphimba njira zokonzekera monga kutsitsi fluidized bed negative pressure vibration granulation.
Izi zimachepetsa kuchuluka kwa ndalama zomwe zimagwiritsidwa ntchito kudzera mu synergistic effect pakati pa zotsekemera. Amagwiritsidwa ntchito pazipatso zamaswiti, zakumwa (monga zakumwa zokhala ndi kaboni), zowotcha, ndi kukonza nyama, kukulitsa moyo wa alumali ndikukulitsa mawonekedwe a kukoma. Zomwe zimapangidwira zimaphatikizanso kusakaniza kwa aspartame ndi shuga wa AK kuti awonjezere kukoma, komanso erythritol ndi maltitol kuti shuga azikoma{{2}zakudya zopanda pake. Kupanga kwapawiri kumakhalanso ndi zopatsa mphamvu zochepa ndipo sikukhudza shuga wamagazi kapena lipids zamagazi.
Sweeteners ndi gulu lofunika kwambiri lazakudya zowonjezera. Panopa, zotsekemera zili m'gulu la{1}}zambiri zogulitsa zakudya padziko lonse lapansi komanso m'dziko langa. Zotsekemera zotsekemera zimafunika: kutetezedwa ndi-kupanda kawopsedwe, kutsekemera kofanana ndi sucrose, kutsekemera kwambiri, kutsika kapena kusakhala ndi zopatsa mphamvu, kukhazikika kwapamwamba, kosatha-cariogenicity, ndi mtengo wokwanira (osapitirira mtengo wa sucrose pansi pa kutsekemera kofananako). Chotsekemera chomwe chimakwaniritsa zofunikira zonsezi sichinapezeke. Komabe, chifukwa cha kuthekera kolumikizana pakati pa zotsekemera zosiyanasiyana, zotsekemera zophatikizika zimapereka zabwino monga kugwiritsa ntchito mosavuta, kutsekemera kwambiri, kutsekemera koyera, komanso kutsika kwamitengo yopangira, zomwe zimawapangitsa kukhala njira yofunikira pakukulitsa ndikugwiritsa ntchito zotsekemera. Kafukufuku akuwonetsa kuti stevia, monga chigawo chachikulu cha zotsekemera, ali ndi zopatsa mphamvu zochepa, kutsekemera kwakukulu, zonse-zachilengedwe, ndi zotetezeka komanso zathanzi, zomwe zimathandiza kuti zotsekemera zikhale ndi zotsekemera, zokometsera, ndi kukhazikika. Kuphatikiza apo, imatha kupangidwa motetezeka ndi thupi la munthu popanda zovuta zilizonse, ndikupangitsa kuti ikhale yofunikira kwambiri pakukula kwa zotsekemera m'zaka za 21st.